91Ó°ÊÓ

Sunday 17 August 2025
91Ó°ÊÓ Foundation Trust

FOI_8741

Internal Reference Number: FOI_8741

Date Request Received: 03/07/2025 00:00:00

Date Request Replied To: 25/07/2025 00:00:00

This response was sent via: By Email

Request Summary: Diffuse Large B Cell Lymphoma (DLBCL)

Request Category: Private Individuals



 
Question Number 1:
In the last 6 months, how many patients have been diagnosed with Diffuse Large B Cell Lymphoma (DLBCL)?

a. Of these patients, how many commenced treatment at your trust within the last 6 months?
 
Answer To Question 1:
In the last 6 months, how many patients have been diagnosed with Diffuse Large B Cell Lymphoma (DLBCL)? 9

Of these patients, how many commenced treatment at your trust within the last 6 months? 7
 
Question Number 2:
In the last 6 months, how many patients have you treated for Diffuse Large B Cell Lymphoma (DLBCL) with the following treatments:

• R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone)

• R-mini-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone)

• Pola-BR (polatuzumab vedotin with rituximab and bendamustine)

• Pola-R-CHP (Polatuzumab vedotin with rituximab, cyclophosphamide, doxorubicin hydrochloride, and prednisolone)

• R-CODOX-M (rituximab, cyclophosphamide, vincristine, doxorubicin and methotrexate)

• R-IVAC (rituximab, ifosfamide, etoposide and cytarabine)

• R-GCVP (Rituximab, gemcitabine, cyclophosphamide, vincristine, prednisolone)

• (DA)-EPOCH +/-R (Prednisolone, doxorubicin, vincristine, etoposide, cyclophosphamide, rituximab)

• R-GemOX (rituximab, gemcitabine and oxaliplatin)

• Axicabtagene ciloleucel

• Tisagenlecleucel

• Epcoritamab

• Loncastuximab tesirine

• Glofitamab

• Any other SACT

• Stem cell transplant or bone marrow transplant (autologous or allogeneic)
 
Answer To Question 2:
See attachment

To accompany this answer to question 2 please also see the documents listed below:

 13107 - FOI_8741 - Diffuse Large B Cell Lymphoma (DLBCL) v1 FOR ISSUE.docx
 
Question Number 3:
. In the last 6 months, how many patients have received the following 2nd line treatments for Diffuse Large B Cell Lymphoma (DLBCL):

• Axicabtagene ciloleucel (Yescarta)

• Tisagenlecleucel

• Pola-BR (polatuzumab vedotin with rituximab and bendamustine)

• R-GemOX (rituximab, gemcitabine and oxaliplatin)

• Stem cell transplant or bone marrow transplant (autologous or allogeneic)

• Any other treatments
 
Answer To Question 3:
For axicabtagene, tisagenlecleucel, RGemOx, stem cell transplant - Zero patients

<5 patients for other treatment,

<5 patients for pola-BR
 
Question Number 4:
In the last 6 months, how many patients has the Trust treated for 3rd line Diffuse Large B Cell Lymphoma (BLBCL)?
 
Answer To Question 4:
<5 patients
 
Question Number 5:
In the last 6 months, how many patients have you referred to other trusts for the treatment of Diffuse Large B Cell Lymphoma (DLBCL) for the following treatments:

• CAR-T Therapy (E.g. Axicabtagene ciloleucel)

• Stem cell transplant or bone marrow transplant (autologous or allogeneic)

• Any other treatment
 
Answer To Question 5:
None
Please see Attachments:
 
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